导师个人简介
蔡志强，男，辽宁人，副教授，药物化学博士，主要从事有机化合物的合成与新药研究。现任沈阳工业大学辽阳分校科研助理、精细化学品研究室主任。曾被评为“阜新杰出科技工作者”，“辽阳五四青年奖章”，“辽阳市最美科技工作者”，第二届“最美青年科技工作者”活动国家级候选人，“沈阳工业大学先进个人”。
参与国家自然科学基金面上项目1项，主持辽宁省科技厅自然科学基金1项，辽宁省教育厅计划项目2项，沈阳市科技局项目1项，沈阳工业大学青年教师培育基金1项；主持横向课题共8项，累计科研进款200余万元，与企业对接实现科技成果转化，为企业增效创益两千余万元。现担任《合成化学》期刊编委，国际知名期刊《Talanta》、《Journal of chromatography A》、《Microchemical Journal》、《Chinese Journal of Structural Chemistry》、《RSC Advances》、《Molecules》、《Russian Journal of General Chemistry》、《Journal of the Chemical Society of Pakistan》、《Journal of chemical research》、《Journal of Porous Materials》等审稿专家。共计申报国家发明专利44项，授权28项；发表国家核心及以上期刊论文86篇，其中SCI论文50余篇。指导硕士研究生30余名，其中3篇硕士学位论文被评为校级优秀论文，1篇硕士学位论文为省级优秀论文提名，3名硕士毕业生被推送攻读博士。
学习和工作简历
2017/12-至今，沈阳工业大学，石油化工学院，副教授
2012/12-2017/12，沈阳工业大学，石油化工学院，讲师
2009/9-2012/12，天津药物研究院，药物创新研究中心，助理研究员
2006/9–2009/9，沈阳药科大学，药物化学，博士
2003/9–2006/7，辽宁大学，有机化学，硕士
1999/10–2003/7，辽宁大学，化学，学士
导师研究方向
（1）抗肿瘤新药及中间体工艺研究；
（2）气相色谱柱固定相研发；
（3）精细化学品合成。
科研项目
1. Superferrocenophane的合成及[3n]Ferrocenophane类化合物(n=2-5)的构造、光谱学和电化学性质研究（编号：20572041），国家自然科学基金委，结题。
2. EGFR/HER2双受体酪氨酸激酶抑制剂抗肿瘤候选药物研究（编号：20180550016），辽宁省科技厅，结题。
3. 基于EGFR靶点的小分子喹唑啉类抗肿瘤药物研究（编号：LJGD2020015），辽宁省教育厅项目，在研。
4. Ⅱa因子抑制剂抗静脉血栓候选药物研究（编号：L2015383），辽宁省教育厅项目，结题。
5. 靶向抗肿瘤类药物中间体研制（编号：18-004-4-32），沈阳市科技局项目，结题。
6. 抗禽流感药物帕拉米韦中间体生产（编号：20180101），辽宁创钜石化技术有限公司，在研。
7. 靶向抗肿瘤类药物中间体技术开发（编号：20170701），沈阳感光化工研究院有限公司，结题。
8. 2-乙基丁醛生产工艺（编号：20150501），北京隆德博科技有限公司，结题。
9. 甲基-2,2-双（4-羟基苯基）乙酸甲酯（MBHA）生产工艺（编号：20150101），沈阳感光化工研究院有限公司，结题。
10. 苯并咪唑类抗凝血药物的合成工艺研究（编号：20130101），大连科雅斯迪科技有限公司，结题。
11. 甲基丙烯酸缩水甘油酯生产工艺（编号：20160901）， 阜新华临新材料科技有限公司，结题。
12. 高性能混凝土外加剂技术开发（编号：20180301）， 阜新奥瑞凯新材料科技有限公司，结题。
授权专利
1. 蔡志强;帅筱敏;孙涛;章围;李伟。 咪唑离子液体功能化的杯四芳烃固定相的制备及其应用，ZL202010430599.8.
2. 蔡志强;韩晓;丁海关;赵臣康;王博;郝林林。 喹唑啉衍生物及其作为抗肿瘤药物的应用，ZL202010439176.2.
3. 蔡志强;赵辰康;王庆林;帅筱敏;付佳;李梦瑶;丁海关;谷雨彤;侯英莉. EGFR和HER2双靶点酪氨酸激酶抑制剂及制备方法和用途，ZL201811318805.5.
4. 蔡志强;帅筱敏;付佳;赵辰康;王庆林;丁海关;侯英莉;谷雨彤;李梦瑶. 杯芳烃衍生物固定相、毛细管气相色谱柱及其制备与应用，ZL201910053428.5
5. 蔡志强;丁海关;赵文凯;侯玲;庄殿铮;杨旭鹏;胡志泉;金正盛。喹唑啉衍生物及其制备方法和用途， ZL201711018330.3.
6. 蔡志强，侯玲，李素君，马维英，刘若灿，张波，杨迪。氮杂苯并薁衍生物及其制备方法和用途，专利号：ZL201410133748.9.
7. 蔡志强，李素君，侯玲，胡志泉，孙洪涛，李志利，郭洪彬，蔡奥飞。喹唑啉衍生物及其制备方法和用途，专利号：ZL201310542061.6.
8. 蔡志强，侯玲，于大伟，孙洪涛，胡志泉，庄殿铮，杨旭鹏。达比加群的酯衍生物及其制备方法和用途，专利号：ZL201610178950.2.
9. 蔡志强，侯玲，侯旭 马维英。达比加群的酯衍生物及其制备方法和用途，专利号：ZL 201510056650.2.
发表文章
[1] Tao Sun*, Ruonan Chen, Qiuchen Huang, Mengyi Ba, Zhiqiang Cai*, Haipeng Chen, Yueheng Qi, Hong Chen, Xianming Liu, Donatella Nardiello and Quinto Maurizio. Efficient separation of xylene isomers by using pillar[6]arene-based stationary phase for capillary gas chromatography. Analytica Chimica Acta. 2023, 1251, 340979.
[2] Tao Sun*, Ruonan Chen, Qiuchen Huang, Mengyi Ba, Zhiqiang Cai*, Shaoqiang Hu, Xianming Liu, Donatella Nardiello and Maurizio Quinto. The chromatographic separation of aromatic amine isomers: a solved issue by a new amphiphilic pillar[6]arene stationary phase. ACS Applied Materials & Interfaces. 2022, 14, 56132-56142.
[3] Qiuchen Huang, Zhiqiang Cai*, Ruonan Chen, Wei Zhang, Yiwen Li, Maurizio Quinto, Xianming Liu, Shaoqiang Hu and Tao Sun*. A new stationary phase for capillary gas chromatography based on amphiphilic triblock copolymer - benzimidazolium ionic liquid. Microchemical Journal, 2022, 183, 108084.
[4] Ruonan Chen, Zhiqiang Cai*, Qiuchen Huang, Wei Zhang, Keyun Jin, Yi Zhao, Yiwen Li, Tao Sun, Hongying Ji and Shuai Li*. Benzimidazolium Ionic-Liquid-Functionalized Star-shaped Copolymer Stationary Phase for Capillary Gas Chromatography. ChemistrySelect, 2022, 7, e202202847.
[5] Ruonan Chen, Zhiqiang Cai*, Qiuchen Huang, Wei Li, Wei Zhang, Yi Zhao, Keyun Jin, Yiwen Li and Tao Sun*. A Bromine‑Terminated Triblock Copolymer (Br‑PCL‑PDMS‑PCL‑Br) as the Stationary Phase for Gas Chromatography Analysis. Chromatographia, 2022, 85, 883–894.
[6] Wei Zhang, Zhiqiang Cai*, Xiaomin Shuai, Wei Li, Qiuchen Huang, Ruonan Chen, Qiqi Zang, Feifei Li and Tao Sun*. Synthesis, Crystal Structure and Separation Performance of p-tert-butyl(tetradecyloxy) calix[6]arene. Acta Chimica Slovenica, 2022, 69, 227-234.
[7] Ruonan Chen, Zhiqiang Cai*, Wei Li, Qiuchen Huang, Donatella Nardiello, Maurizio Quinto, Xianming Liu, Shaoqiang Hu and Tao Sun*. A new capillary gas chromatography column based on poly (ethylene glycol) methyl ether-functionalized calix[4]arene. Chemistry & Biodiversity, 2022, e202200829.
[8] Qiuchen Huang, Zhiqiang Cai*, Wei Li, Ruonan Chen, Wei Zhang, Keyun Jin, Yi Zhao, Yiwen Li and Tao Sun*. Novel, selective calix[6]arene-polyethylene glycol (C6A-PEG) stationary phase for capillary gas chromatography (GC). Analytical Letters. DOI: 10.1080/00032719.2022.2143794
[9] Qiuchen Huang, Zhiqiang Cai*, Ruonan Chen, Wei Li, Wei Zhang, Yi Zhao, Keyun Jin, Yiwen Li, Tao Sun* and Wentao Liu*. Separation performance of the calix[8]arene functionalized with polyethylene glycol units for capillary gas chromatography. Analytical Sciences.
[10] Ruonan Chen, Zhiqiang Cai*, Wei Zhang, Qiuchen Huang, Wei Li, Keyun Jin, Yi Zhao, Ge Feng and Tao Sun*. An amphiphilic star-shaped polymer (Star-PEG-PCL2) used as a stationary phase for GC. Acta Chimica Slovenica. 2022,12.
[11] Wei Zhang, Zhiqiang Cai*, Wei Li, Qiuchen Huang, Ruonan Chen, Yiwen Li, Keyun Jin, Yi Zhao and Tao Sun*. Separation performance of PEG-linked calix[4]arene as stationary phase for capillary gas chromatography. Química Nova. DOI: 10.21577/0100-4042.20230013
[12] Liang-liang Chi, Lin-lin Hao, Zhi-qiang Cai*, et al. Design, synthesis and biological evaluation of novel larotrectinib derivatives as potent antitumor agents. Russ. J. Gen. Chem., 2022, 92(12):2708-2722.
[13] Tao Sun*, Qiuchen Huang, Wei Zhang, Ruonan Chen, Wei Li, Haipeng Chen, Shaoqiang Hu and Zhiqiang Cai* Amphiphilic pillar[5]arene as a novel stationary phase for capillary gas chromatography. Journal of Chromatography A, 2022,1671,463008.
[14] Bo Wang, Zhi-qiang Cai*, Xiao-yu Shi, Xiang Li, Shuai Li*, and Ji-xin Li*. Synthesis, Crystal Structure and Anticancer Activity of Substituted Quinazoline Derivatives. Journal of the Chemical Society of Pakistan，2021, 43(4): 466-474.
[15] Han Xiao, Cai Zhi-Qiang, Wu Li-Hua*, Hou Ling**, Li Shuai. Synthesis, Biological Activity, and Crystal Structure of N,N-Diethyl-2-((7-methoxy-4-(phenylamino)quinazolin-6-yl)oxy) Acetamide. Russian Journal of General Chemistry, 2021, 91(11): 2286-2291.
[16] Liang-liang Chi, Zhi-qiang Cai*, Bo Wang, Wei-tao Qin, Ya-nan Wang, Qiao-qiao Feng*, and Wen-jie Ren. Design, synthesis and biological evaluation of several novel 4-aniline quinazoline derivatives as potent anti-tumor agents. Journal of the Chemical Society of Pakistan, 2023, 45(06).
[17] Ya-Nan Wang, Zhi-Qiang Cai, Chen-Kang Zhao, Bo-Wang, Liang-Liang Chi, Wei-Tao Qin, Li-Hua Wu, De-Qiang Zheng. Novel 4-arylaminoquinazoline derivatives: design, synthesis and biological evaluation as potent antitumor agents. Molecular Crystals and Liquid Crystals.2022,12,
[18] Tao Sun, Qiuchen Huang, Ruonan Chen, Wei Zhang, Qionglu Li, Aoping Wu, Guixia Wang, Shaoqiang Hu and Zhiqiang Cai*. The selectivity of polydimethylsiloxane-based triblock copolymer as stationary phase for capillary gas chromatography, New. J. Chem. 2021, 45: 20459-20467.
[19] Tao Sun, Xiaomin Shuai, Yujie Chen, Xinyu Zhao, Qianqian Song, Kaixin Ren, Xingxing Jiang, Shaoqiang Hu and Zhiqiang Cai*, Separation performance of p-tert-butyl(tetradecyloxy)calix[6]arene as a stationary phase for capillary gas chromatography, RSC Advances. 2019, 9( 66): 38486-38495.
[20] Tao Sun, Liran Qi, Weiwei Li, Yan Li, Xiaomin Shuai, Zhiqiang Cai, Haipeng Chen, Xiaoguang Qiao and Lufang Ma. Amphiphilic calix[4]arenes as a highly selective gas chromatographic stationary phase for aromatic amine isomers. Journal of Chromatography A, 2019, 1601(13): 310-318.
[21] Tao Sun, Bin Li, Xiaomin Shuai, Yujie Chen, WeiWei Li, Zhiqiang Cai*, Xiaoguang Qiao, Shaoqiang Hu and Lufang Ma, Performance and selectivity of lower-rim substituted calix[4]arene as a stationary phase for capillary gas chromatography, RSC. Adv. 2019, 9(37): 21207-21214.
[22] Tao Sun, Bin Li,,Yan Li, Xinyu Zhao, Qianqian Song,Xingxing Jiang, Xiaomin Shuai , Youyang Li, Zhiqiang Cai*, Shaoqiang Hu, Amphiphilic Star‑Shaped Calix[4]resorcinarene as Stationary Phase for Capillary Gas Chromatography, Chromatographia. 2019, 82(11): 1697-1708.
[23] Tao Sun, Xingxing Jiang, Qianqian Song, Xiaomin Shuai, Yujie Chen, Xinyu Zhao, Zhiqiang Cai*, Ke Li, Xiaoguang Qiao and Shaoqiang Hu, Star-poly(3-caprolactone) as the stationary phase for capillary gas chromatographic separation, RSC. Adv. 2019, 9(49): 28783-28792.
[24] Tao Sun, Xiaomin Shuai, Kaixin Ren, Xingxing Jiang, Yujie Chen, Xinyu Zhao, Qianqian Song, Shaoqiang Hu and Zhiqiang Cai*, Amphiphilic Block Copolymer PCL-PEG-PCL as Stationary Phase for Capillary Gas Chromatographic Separations, Molecules. 2019, 24(17): 3158-3171.
[25] Tao Sun, Xiaomin Shuai, Li Bin, Kaixin Ren, Xingxing Jiang, Haipeng Chen, Shaoqiang Hu and Zhiqiang Cai*, p-Nitro-tetradecyloxy-calix[4]arene as a highly selective stationary phase for gas chromatographic separations, New. J. Chem. 2019, 43(43): 16960-16967.
[26] Hai-Guan Ding, Zhi-Qiang Cai*, Ling Hou, Zhi-quan Hu, Zheng-sheng Jin, Di Xu, Hui Cao, Miao-Miao Meng, Yu-Hui Xie, De-qiang Zheng*.Synthesis and Evaluation of Some Novel 6-Substituted Quinazoline Derivatives as Antitumor Agents. Journal of the Chemical Society of Pakistan，2019，41(1)：186-190.
[27] Zhi-Qiang Cai,Chen-kang Zhao, Meng-Yao Li, Xiao-Min Shuai, Hai-Guan Ding, Shu-Hui Fang, Zheng-Sheng Jin, Shuai Li* and Le-Jing Zhao. Synthesis, Crystal Structure, and Biological Activity of 6-(3-chloropropoxy)-N-(2-fluorophenyl) -7-methoxyquinazolin-4-amine Ethyl acetate Complex, Journal of chemical research. 2019, 43 (4):97-100.
[28] Yan Zhang, Qing Lv, Meiling Qi*, Zhiqiang Cai*.Performance of permethyl pillar[5]arene stationary phase forhigh-resolution gas chromatography, Journal of Chromatography A, 2017,1496,115-121.
[29] Zhiqiang Cai*, Xu Hou, Ling Hou, Zhiquan Hu, Bo Zhang, Zhengsheng Jin.One-pot Pd(II)- Catalyzed Synthesis of Fluorenones via Decarboxylative Cyclization. SYNLETT, 2016, 27(3): 395-398.
[30] CAI Zhi-Qiang*, HOU Xu, Du-Lin Kong, HOU Ling and HU Zhi-Quan. Synthesis, crystal structural, and spectral characterization of dabigatran etexilate tetrahydrate. Journal of Chemical Research, 2016, 40 (8): 461 -466.
[31] Zhi-qiang Cai, Zheng-sheng Jin, De-qiang Zheng, Ling Hou, Guan-wang Huang, Jun-qiang Tian, Guo-jiang Wang. Synthesis of several new quinazolin-4-amines containing p-toluene sulfonate moiety. Journal of chemical research. 2016, 40 (9):573-575.
[32] Ju Liu, Xin-wei Zhang , Yang Wang , Ye Chen, Mei-rong Zhang, Zhi-qiang Cai, Yun-peng Zhou, Li-feng Xu. A new efficient synthesis of 4- alkoxy -1,6-diaryl-1H -pyrazolo[3,4-d] pyrimidine derivatives. Synthetic Communications, 2015, 45(8):1009-1017.
[33] Ju Liu, Xin-Wei Zhang, Duan-Zheng Song, Zhi-qiang Cai and Yun-peng Zhou. Synthesis of several new 1-arylpyrazolo[3,4-d]pyrimidines containing an amide moiety. Journal of chemical research. 2016, 40 (7):92-94.
[34] Zhi-Qiang Cai, Ju Liu, Ming-Xiang Shao, Yang Wang, Mei-Rong Zhang, Ye Chen, Li-Feng Xu and Min Gong A Cup-like Structure: Synthesis,Crystal Structure and Anti-Cancer Activity of 2-(2-(4,5-diphenyl-1H- imidazol-1-yl)acetamido)ethyladamantane -1-carboxylate，Journal of The Chemical Society of Pakistan, 2014, 36(4): 717-722.
[35] Cai Zhi-Qiang*，Ma Wei-Ying，Liu Ju，Hu Zhi-Quan，Hou Ling，Wang Jian-Ya Synthesis, Crystal Structure and Biological Activity of a New 4,5-Diaryl-1H-imidazole Derivative，Chinese Journal of Structural Chemistry,2014,33(9):1383-1387.
